EPHA1 anticorps (AA 453-487)

N° du produit ABIN6577926

Détail du produit anti-EPHA1 anticorps

Antigène: EPHA1 (Ephrin Type A Receptor 1 (EPHA1))

Épitope: AA 453-487

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPHA1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This mouse Epha1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 453-487 amino acids from the Central region of mouse Epha1.

Clone: RB51137

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur EPHA1

Antigène: EPHA1 (Ephrin Type A Receptor 1 (EPHA1))

Autre désignation: Epha1 (EPHA1 Produits)

Synonymes: anticorps EPH, anticorps EPHT, anticorps EPHT1, anticorps 5730453L17Rik, anticorps AL033318, anticorps Eph, anticorps Esk, anticorps EPHA9, anticorps EPH receptor A1, anticorps Eph receptor A1, anticorps EPHA1, anticorps Epha1

Sujet: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Poids moléculaire: 108578

UniProt: Q60750