DOT1L anticorps (C-Term)

N° du produit ABIN6243177

Détail du produit anti-DOT1L anticorps

Antigène: DOT1L (DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L))

Épitope: AA 1390-1420, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DOT1L est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This KMT4 / Dot1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1390~1420 amino acids from the C-terminal region of human DOT1L.

Clone: RB2773

Isotype: Ig Fraction

Information d'application

Indications d'application: IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-DOT1L (ABIN6243177)

Nguyen, Xiao, Neppl, Kallin, Li, Chen, Wang, Xiao, Zhang: "DOT1L regulates dystrophin expression and is critical for cardiac function." dans: Genes & development, Vol. 25, Issue 3, pp. 263-74, (2011) (PubMed).

Comty, Wathen, Shapiro: "Uremic pericarditis." dans: Cardiovascular clinics, Vol. 7, Issue 3, pp. 219-35, (1977) (PubMed).

Détails sur DOT1L

Antigène: DOT1L (DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L))

Autre désignation: KMT4 / Dot1L (DOT1L Produits)

Synonymes: anticorps NV11307, anticorps DOT1L, anticorps DOT1, anticorps KMT4, anticorps A630076O07, anticorps AW907654, anticorps Dot1, anticorps mDot1, anticorps histone-lysine N-methyltransferase, H3 lysine-79 specific, anticorps DOT1 like histone lysine methyltransferase, anticorps histone methyltransferase, anticorps DOT1-like, histone H3 methyltransferase (S. cerevisiae), anticorps LOC100116648, anticorps DOT1L, anticorps DOT1, anticorps Dot1l

Sujet: Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.

Poids moléculaire: 164856

NCBI Accession: NP_115871

UniProt: Q8TEK3