YES1 anticorps (N-Term)

N° du produit ABIN6243290

Détail du produit anti-YES1 anticorps

Antigène: YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))

Épitope: AA 112-147, N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YES1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This YES1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 112-147 amino acids from the N-terminal region of human YES1.

Clone: RB50776

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur YES1

Antigène: YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))

Autre désignation: YES1 (YES1 Produits)

Synonymes: anticorps HsT441, anticorps P61-YES, anticorps Yes, anticorps c-yes, anticorps yes, anticorps p61-Yes, anticorps hst441, anticorps p61-yes, anticorps YES, anticorps c-Yes, anticorps p60c-yes, anticorps YES proto-oncogene 1, Src family tyrosine kinase, anticorps YES proto-oncogene 1, Src family tyrosine kinase L homeolog, anticorps YES1, anticorps yes1.L, anticorps yes1, anticorps Yes1

Sujet: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Poids moléculaire: 60801

UniProt: P07947

Pathways: CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling