FOXA1 anticorps (AA 372-472)

N° du produit ABIN6251997

Détail du produit anti-FOXA1 anticorps

Antigène: FOXA1 (Forkhead Box A1 (FOXA1))

Épitope: AA 372-472

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FOXA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Specificité: Does not react with rat

Purification: Protein G affinity chromatography

Immunogène: A human partial recombinant protein corresponding to amino acids 372-472 was used as the immunogen for this FOXA1 antibody.

Clone: FOXA1-1512

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow Cytometry: 0.5-1 μg/10^6 cells

IF: 1-2 μg/mL

WB: 0.5-1 μg/mL

IHC (FFPE): 1-2 μg/mL for 30 min at RT

Optimal dilution of the FOXA1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Détails sur FOXA1

Antigène: FOXA1 (Forkhead Box A1 (FOXA1))

Autre désignation: FOXA1 (FOXA1 Produits)

Synonymes: anticorps HNF3A, anticorps TCF3A, anticorps Hnf-3a, anticorps Hnf3a, anticorps Tcf-3a, anticorps Tcf3a, anticorps fkd7, anticorps forkhead-7, anticorps HNF3-alpha, anticorps HNF3alpha, anticorps fkh2, anticorps foxa1, anticorps hnf3a, anticorps tFoxA1, anticorps tcf3a, anticorps xfkh2, anticorps fkh, anticorps FOXA1, anticorps Ci-fkh, anticorps HNF-3a, anticorps forkhead box A1, anticorps forkhead box A1 S homeolog, anticorps forkhead homolog, anticorps forkhead box A1 L homeolog, anticorps FOXA1, anticorps Foxa1, anticorps foxa1, anticorps foxa1.S, anticorps fkh, anticorps foxa1.L

Sujet: FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin as a pioneer factor. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.

FOXA1 in breast cancer is highly correlated with ERalpha+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 acts as a pioneer factor for ERa in ERalpha+ breast cancer, and its expression might identify ERalpha+ cancers that undergo rapid reprogramming of ERa signaling that is associated with poor outcomes and treatment resistance. Conversely, in ERalpha−, breast cancer FOXA1 is highly correlated with low-grade morphology and improved disease free survival. FOXA1 is a downstream target of GATA3 in the mammary gland. Expression in ERalpha−, cancers may identify a subset of tumors that is responsive to other endocrine therapies such as androgen receptor antagonist treatment. [Wiki]

ID gène: 3169

UniProt: P55317

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis