Filaggrin anticorps
-
- Antigène Voir toutes Filaggrin (FLG) Anticorps
- Filaggrin (FLG)
-
Reactivité
- Humain
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp Filaggrin est non-conjugé
-
Application
- Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
- Purification
- Protein G affinity chromatography
- Immunogène
- A recombinant human FLG protein was used as the immunogen for this Filaggrin antibody.
- Clone
- SPM181
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product FLG Anticorps primaire
-
-
- Indications d'application
-
Flow Cytometry: 0.5-1 μg/10^6 cells in 0.1ml
IF: 1-2 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 min at RT
Optimal dilution of the Filaggrin antibody should be determined by the researcher. - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.2 mg/mL
- Buffer
- PBS with 0.1 mg/mL BSA and 0.05 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Aliquot and Store at -20C. Avoid freez-thaw cycles.
-
- Antigène
- Filaggrin (FLG)
- Autre désignation
- Filaggrin (FLG Produits)
- Synonymes
- anticorps AW107830, anticorps ft, anticorps FLG, anticorps ATOD2, anticorps Pflg, anticorps Flg, anticorps filaggrin, anticorps Flg, anticorps FLG, anticorps LOC100351762, anticorps LOC100728006
- Sujet
-
Filaggrin (filament aggregating protein) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten to twelve filaggrin units are post-translationally hydrolized from a large profilaggrin precursor protein during terminal differentiation of epidermal cells. In humans, profilaggrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation complex on chromosome 1q21.
Filaggrin is essential for the regulation of epidermal homeostasis. Within the stratum corneum, filaggrin monomers can become incorporated into the lipid envelope, which is responsible for the skin barrier function. Alternatively, these proteins can interact with keratin intermediate filaments. Filaggrin undergoes further processing in the upper stratum corneum to release free amino acids that assist in water retention. [Wiki]
- ID gène
- 2312
- UniProt
- P20930
- Pathways
- Sensory Perception of Sound, Stem Cell Maintenance
-