SERPINA1 anticorps

N° du produit ABIN6252582

Détail du produit anti-SERPINA1 anticorps

Antigène: SERPINA1 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SERPINA1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Protein G affinity

Immunogène: A human partial recombinant protein was used as the immunogen for this Alpha 1 Antitrypsin antibody.

Clone: AAT-1379

Isotype: IgG1

Information d'application

Indications d'application: Western blot: 0.5-1 μg/mL

IHC (Paraffin): 0.5-1 μg/mL

IF: 0.5-1 μg/mL

Flow Cytometry: 0.5-1 μg/10e6 cells in 0.1ml

Titration of the Alpha 1 Antitrypsin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Détails sur SERPINA1

Antigène: SERPINA1 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1))

Autre désignation: Alpha 1 Antitrypsin (SERPINA1 Produits)

Synonymes: anticorps AACT, anticorps ACT, anticorps GIG25, anticorps A1AT, anticorps PI, anticorps alpha-1-PI, anticorps A1A, anticorps AAT, anticorps PI1, anticorps PRO2275, anticorps alpha1AT, anticorps Pi, anticorps Spi1, anticorps MGC64429, anticorps serpina1d, anticorps Aps, anticorps SERPINA3-5, anticorps serpin family A member 3, anticorps alpha-1-antiproteinase F precursor, anticorps serpin family A member 1, anticorps alpha-1-antitrypsin, anticorps calumenin, anticorps serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog, anticorps serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, anticorps serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5, anticorps SH2B adaptor protein 2, anticorps serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3, anticorps serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 L homeolog, anticorps SERPINA3, anticorps LOC100008973, anticorps SERPINA1, anticorps LOC100328621, anticorps CALU, anticorps Serpina1, anticorps serpina1.S, anticorps serpina1, anticorps SPIA5, anticorps Sh2b2, anticorps Calu, anticorps serpina1.L

Sujet: Alpha-1 Antitrypsin or alpha1-antitrypsin (A1AT) is a protease inhibitor belonging to the serpin superfamily. It is generally known as serum trypsin inhibitor. Alpha 1-antitrypsin is also referred to as alpha-1 proteinase inhibitor (A1PI) because it inhibits a wide variety of proteases. It protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has a reference range in blood of 1.5 - 3.5 gram/liter (in US the reference range is generally expressed as mg/dL or micromoles), but the concentration can rise manyfold upon acute inflammation. In its absence (such as in alpha 1-antitrypsin deficiency), neutrophil elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (chronic obstructive pulmonary disease) in adults and cirrhosis in adults or children.

Like all serine protease inhibitors, A1AT has a characteristic secondary structure of beta sheets and alpha helices. Mutations in these areas can lead to non-functional proteins that can polymerise and accumulate in the liver (infantile hepatic cirrhosis). [Wiki]

ID gène: 5265

UniProt: P01009