ITPR1 anticorps (pSer1756, pSer1764)
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- Antigène Voir toutes ITPR1 Anticorps
- ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))
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Épitope
- pSer1756, pSer1764
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ITPR1 est non-conjugé
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Application
- ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- Phospho-IP3 Receptor (Ser1756) Antibody detects endogenous levels of IP3 Receptor only when phosphorylated at Ser1756.
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogène
- A synthesized peptide derived from RAT IP3 Receptor(P29994) around the phosphorylation site of Ser1756. This site is equivalent to Ser1764 in the human IP3 receptor sequence.
- Isotype
- IgG
- Top Product
- Discover our top product ITPR1 Anticorps primaire
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- Indications d'application
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))
- Autre désignation
- ITPR1 (ITPR1 Produits)
- Synonymes
- anticorps D6Pas2, anticorps ENSMUSG00000072853, anticorps Gm10429, anticorps IP3R1, anticorps InsP3R, anticorps Ip3r, anticorps Itpr-1, anticorps P400, anticorps Pcp-1, anticorps Pcp1, anticorps opt, anticorps I145TR, anticorps InsP3R1, anticorps INSP3R1, anticorps IP3R, anticorps SCA15, anticorps SCA16, anticorps SCA29, anticorps inositol 1,4,5-trisphosphate receptor type 1, anticorps inositol 1,4,5-trisphosphate receptor 1, anticorps inositol 1,4,5-trisphosphate receptor, type 1, anticorps ITPR1, anticorps Itpr1
- Sujet
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Description: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
Gene: ITPR1
- Poids moléculaire
- 314kDa
- ID gène
- 3708
- UniProt
- Q14643
- Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, Synaptic Membrane, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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