ITPR1 anticorps (AA 2411-2758)

N° du produit ABIN3043862

Détail du produit anti-ITPR1 anticorps

Antigène: ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))

Épitope: AA 2411-2758

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ITPR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Inositol 1,4,5-trisphosphate receptor type 1(ITPR1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Inositol 1,4,5-trisphosphate receptor type 1(ITPR1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: inositol 1,4,5-trisphosphate receptor, type 1
Protein Name: Inositol 1,4,5-trisphosphate receptor type 1

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human IP3 receptor recombinant protein (Position: A2411-A2758). Human IP3 receptor shares 98% and 97% amino acid (aa) sequences identity with mouse and rat IP3 receptor, respectively.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, The detection limit for IP3 receptor is approximately 0.2 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-ITPR1 (ABIN3043862)

Yu, Chen, Wang, Kuang, Liu, Zhang, Du: "Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-?B and STAT3 in transient focal stroke." dans: PLoS ONE, Vol. 8, Issue 2, pp. e55839, (2013) (PubMed).

Détails sur ITPR1

Antigène: ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))

Autre désignation: ITPR1 (ITPR1 Produits)

Synonymes: anticorps D6Pas2, anticorps ENSMUSG00000072853, anticorps Gm10429, anticorps IP3R1, anticorps InsP3R, anticorps Ip3r, anticorps Itpr-1, anticorps P400, anticorps Pcp-1, anticorps Pcp1, anticorps opt, anticorps I145TR, anticorps InsP3R1, anticorps INSP3R1, anticorps IP3R, anticorps SCA15, anticorps SCA16, anticorps SCA29, anticorps inositol 1,4,5-trisphosphate receptor type 1, anticorps inositol 1,4,5-trisphosphate receptor 1, anticorps inositol 1,4,5-trisphosphate receptor, type 1, anticorps ITPR1, anticorps Itpr1

Sujet: Inositol 1,4,5-trisphosphate receptor type 1, also known as IP3R or IP3R1, is a protein that in humans is encoded by the ITPR1 gene. It is mapped to 3p26.1. The product of the ITPR1 gene is predominantly enriched in cerebellar Purkinje cells but is also concentrated in neurons in the hippocampal CA1 region, caudate-putamen, and cerebral cortex. The ITPR1 gene encodes the inositol 1,4,5-triphosphate(IP3) receptor, an intracellular IP3-gated calcium channel that modulates intracellular calcium signaling. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders.

Synonyms: 4 antibody|5-trisphosphate receptor antibody|5-trisphosphate receptor type 1 antibody|DKFZp313E1334 antibody|DKFZp313N1434 antibody|inositol 1 4 5 triphosphate receptor type 1 antibody|Inositol 1 4 5 trisphosphate Receptor Type 1 antibody|Inositol 1 antibody|Inositol 145-trisphosphate Receptor Type 1 antibody|InsP3R1 antibody|IP3 antibody|IP3 receptor antibody|IP3 receptor isoform 1 antibody|IP3R 1 antibody|IP3R antibody|IP3R1 antibody|ITPR 1 antibody|Itpr1 antibody|ITPR1_HUMAN antibody|SCA15 antibody|SCA16 antibody|SCA29 antibody|Type 1 inositol 1 4 5 trisphosphate receptor antibody|Type 1 inositol 1 antibody|Type 1 InsP3 receptor antibody

ID gène: 3708

UniProt: Q14643

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, Synaptic Membrane, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma