FOXO3 anticorps (pSer253)

N° du produit ABIN6255131

Cet anticorps Lapin Polyclonal détecte spécifiquement FOXO3 dans WB, IHC, ELISA, IF et ICC. Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 1 publication.

Aperçu rapide pour FOXO3 anticorps (pSer253) (ABIN6255131)

Antigène: FOXO3 (Forkhead Box O3 (FOXO3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXO3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-FOXO3 anticorps

Épitope: pSer253

Specificité: Phospho-FOXO3A (Ser253) Antibody detects endogenous levels of FOXO3A only when phosphorylated at Serine 253.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human FOXO3A around the phosphorylation site of Ser253.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Références pour anticorps anti-FOXO3 (ABIN6255131)

Yang, Lv, Chen, Wang, Liu, Shi, Liu, Wang: "The effect of vitamin D on sarcopenia depends on the level of physical activity in older adults." dans: Journal of cachexia, sarcopenia and muscle, Vol. 11, Issue 3, pp. 678-689, (2021) (PubMed).

Détails sur FOXO3

Antigène: FOXO3 (Forkhead Box O3 (FOXO3))

Autre désignation: FOXO3

Sujet:

Description: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301).

Gene: FOXO3

Poids moléculaire: 97kDa

ID gène: 2309

UniProt: O43524

Pathways: Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis