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PKC zeta anticorps (pThr560)

PRKCZ Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6256579
  • Antigène Voir toutes PKC zeta (PRKCZ) Anticorps
    PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))
    Épitope
    • 37
    • 29
    • 16
    • 13
    • 8
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr560
    Reactivité
    • 121
    • 63
    • 42
    • 9
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 133
    • 3
    • 1
    Lapin
    Clonalité
    • 122
    • 15
    Polyclonal
    Conjugué
    • 62
    • 10
    • 10
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp PKC zeta est non-conjugé
    Application
    • 104
    • 62
    • 38
    • 26
    • 26
    • 21
    • 18
    • 9
    • 7
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Phospho-PKC zeta (Thr560) Antibody detects endogenous levels of PKC zeta only when phosphorylated at Threonine 560
     Réactivité croisée
    Humain, Souris, Rat (Rattus)
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogène
    A synthesized peptide derived from human PKC zeta around the phosphorylation site of Threonine 560
    Isotype
    IgG
    Top Product
    Discover our top product PRKCZ Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C.Stable for 12 months from date of receipt
    Date de péremption
    12 months
  • Antigène
    PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))
    Autre désignation
    PKC zeta (PRKCZ Produits)
    Synonymes
    anticorps TPKC, anticorps PKCzeta, anticorps prkcz-A, anticorps pkc-zeta, anticorps PRKCZ, anticorps pkc2, anticorps PKC-ZETA, anticorps PKC2, anticorps AI098070, anticorps C80388, anticorps Pkcz, anticorps R74924, anticorps aPKCzeta, anticorps zetaPKC, anticorps 14-3-3-zetaisoform, anticorps r14-3-3, anticorps pkcz, anticorps si:ch211-150o23.4, anticorps protein kinase C zeta L homeolog, anticorps protein kinase C zeta, anticorps protein kinase C, zeta, anticorps prkcz.L, anticorps PRKCZ, anticorps prkcz, anticorps Prkcz
    Sujet

    Description: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651).

    Gene: PRKCZ

    Poids moléculaire
    80kDa
    ID gène
    5590
    UniProt
    Q05513
    Pathways
    Signalisation NF-kappaB, Signalisation RTK, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Membrane, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
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