SAMHD1 anticorps (pThr592)

N° du produit ABIN6256587

Détail du produit anti-SAMHD1 anticorps

Antigène: SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))

Épitope: pThr592

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SAMHD1 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: Phospho-SAMHD1 (Thr592) Antibody detects endogenous levels of SAMHD1 only when phosphorylated at Thr592.

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human SAMHD1 around the phosphorylation site of Thr592.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SAMHD1

Antigène: SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))

Autre désignation: SAMHD1 (SAMHD1 Produits)

Synonymes: anticorps CHBL2, anticorps DCIP, anticorps HDDC1, anticorps MOP-5, anticorps SBBI88, anticorps si:dkeyp-44b8.8, anticorps E330031J07Rik, anticorps Mg11, anticorps SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1, anticorps SAM domain and HD domain 1, anticorps SAM domain and HD domain, 1, anticorps SAMHD1, anticorps samhd1, anticorps Samhd1

Sujet:

Description: Host restriction nuclease involved in defense response to virus. Has dNTPase activity and reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur. Blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May play a role in mediating proinflammatory responses to TNF-alpha signaling (PubMed:18546154, PubMed:19525956, PubMed:22056990, PubMed:24336198, PubMed:28229507). Has ribonuclease activity, acting on single-stranded RNA. This activity is essential for H1V-1 restriction (PubMed:25038827).

Gene: SAMHD1

Poids moléculaire: 72kDa

ID gène: 25939

UniProt: Q9Y3Z3