MOBKL1A anticorps (N-Term)

N° du produit ABIN6257009

Cet anticorps Lapin Polyclonal détecte spécifiquement MOBKL1A dans WB, ELISA, IF et ICC. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour MOBKL1A anticorps (N-Term) (ABIN6257009)

Antigène: MOBKL1A (MOB1B) (MOB Kinase Activator 1B (MOB1B))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MOBKL1A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-MOBKL1A anticorps

Épitope: N-Term

Specificité: MOB1A Antibody detects endogenous levels of total MOB1A.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human MOB1A, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur MOBKL1A

Antigène: MOBKL1A (MOB1B) (MOB Kinase Activator 1B (MOB1B))

Autre désignation: MOB1B

Sujet:

Description: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Gene: MOB1B

Poids moléculaire: 25 kDa

ID gène: 92597

UniProt: Q7L9L4