GPR161 anticorps (Internal Region)

N° du produit ABIN6257220

Détail du produit anti-GPR161 anticorps

Antigène: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPR161 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: GPR161 Antibody detects endogenous levels of total GPR161.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human GPR161, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur GPR161

Antigène: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Autre désignation: GPR161 (GPR161 Produits)

Synonymes: anticorps RE2, anticorps Gm208, anticorps Gm208Gpr, anticorps vl, anticorps RGD1563245, anticorps si:bz20i5.4, anticorps si:rp71-20i5.4, anticorps G protein-coupled receptor 161, anticorps GPR161, anticorps Gpr161, anticorps gpr161

Sujet:

Description: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

Gene: GPR161

Poids moléculaire: 65 kDa

ID gène: 23432

UniProt: Q8N6U8

Pathways: cAMP Metabolic Process