CCAR1 anticorps (Internal Region)

N° du produit ABIN6257689

Détail du produit anti-CCAR1 anticorps

Antigène: CCAR1 (Cell Division Cycle and Apoptosis Regulator 1 (CCAR1))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCAR1 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: CCAR1 Antibody detects endogenous levels of total CCAR1.

Homologie: Bovine,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CCAR1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur CCAR1

Antigène: CCAR1 (Cell Division Cycle and Apoptosis Regulator 1 (CCAR1))

Autre désignation: CCAR1 (CCAR1 Produits)

Synonymes: anticorps CCAR1, anticorps KIAA1967, anticorps ccar1, anticorps MGC81663, anticorps zehn1480, anticorps hm:zehn1480, anticorps si:dkey-85g17.2, anticorps RP11-437A18.1, anticorps CARP-1, anticorps 2610511G16Rik, anticorps 9430036H15Rik, anticorps Carp1, anticorps RGD1560358, anticorps cell division cycle and apoptosis regulator 1, anticorps cell division cycle and apoptosis regulator 1 L homeolog, anticorps cell division cycle and apoptosis regulator protein 1, anticorps CCAR1, anticorps ccar1.L, anticorps LOC5575286, anticorps ccar1, anticorps LOC409891, anticorps Ccar1

Sujet:

Description: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).

Gene: CCAR1

Poids moléculaire: ?132 kDa

ID gène: 55749

UniProt: Q8IX12