TAO Kinase 2 anticorps (Internal Region)

N° du produit ABIN6257734

Détail du produit anti-TAO Kinase 2 anticorps

Antigène: TAO Kinase 2 (TAOK2)

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAO Kinase 2 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: TAO2 Antibody detects endogenous levels of total TAO2.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TAO2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur TAO Kinase 2

Antigène: TAO Kinase 2 (TAOK2)

Autre désignation: TAOK2 (TAOK2 Produits)

Synonymes: anticorps MAP3K17, anticorps PSK, anticorps PSK1, anticorps PSK1-BETA, anticorps TAO1, anticorps TAO2, anticorps Tao2, anticorps 1110033K02Rik, anticorps B230344N16, anticorps mKIAA0881, anticorps TAOK2, anticorps map3k17, anticorps psk, anticorps psk1, anticorps tao1, anticorps tao2, anticorps TAO kinase 2, anticorps TAO kinase 2 L homeolog, anticorps serine/threonine-protein kinase TAO2, anticorps TAOK2, anticorps Taok2, anticorps taok2.L, anticorps taok2, anticorps LOC100085396

Sujet:

Description: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.

Gene: TAOK2

Poids moléculaire: 120 kDa

ID gène: 9344

UniProt: Q9UL54

Pathways: Cell-Cell Junction Organization