AAK1 anticorps (Internal Region)

N° du produit ABIN6257901

Détail du produit anti-AAK1 anticorps

Antigène: AAK1 (AP2 associated kinase 1 (AAK1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AAK1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: AAK1 Antibody detects endogenous levels of total AAK1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human AAK1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur AAK1

Antigène: AAK1 (AP2 associated kinase 1 (AAK1))

Autre désignation: AAK1 (AAK1 Produits)

Synonymes: anticorps 5530400K14Rik, anticorps 9630042K20, anticorps AU067724, anticorps AU067726, anticorps BC028270, anticorps C79663, anticorps D6Ertd245e, anticorps R75501, anticorps mKIAA1048, anticorps RGD1563580, anticorps aak1, anticorps si:dkey-261l11.5, anticorps AP2 associated kinase 1, anticorps uncharacterized protein FLJ45252, anticorps AP2 associated kinase 1b, anticorps AAK1, anticorps Aak1, anticorps LOC100512341, anticorps aak1b

Sujet:

Description: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.

Gene: AAK1

Poids moléculaire: 94 kDa

ID gène: 22848

UniProt: Q2M2I8