ZFP36L2 anticorps (Internal Region)

N° du produit ABIN6259621

Détail du produit anti-ZFP36L2 anticorps

Antigène: ZFP36L2 (Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZFP36L2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: TISD Antibody detects endogenous levels of total TISD.

Homologie: Pig,Bovine,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TISD, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ZFP36L2

Antigène: ZFP36L2 (Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2))

Autre désignation: ZFP36L2 (ZFP36L2 Produits)

Synonymes: anticorps BRF2, anticorps ERF-2, anticorps ERF2, anticorps RNF162C, anticorps TIS11D, anticorps Brf2, anticorps Tis11d, anticorps fi22c11, anticorps wu:fi22c11, anticorps zgc:76924, anticorps ZFP36L2, anticorps XC3H-3, anticorps XC3H-3b, anticorps c3h-3, anticorps zfp36l2, anticorps brf2, anticorps erf-2, anticorps erf2, anticorps rnf162c, anticorps tis11d, anticorps cb198, anticorps cb480, anticorps fk89d11, anticorps id:ibd1247, anticorps sb:cb198, anticorps sb:cb480, anticorps wu:fb80h11, anticorps wu:fb92f07, anticorps wu:fk89d11, anticorps zfp36l1, anticorps zgc:153979, anticorps XC3H-2, anticorps berg36, anticorps brf1, anticorps c3h-2, anticorps cmg1, anticorps erf-1, anticorps erf1, anticorps rnf162b, anticorps tis11b, anticorps zfp36l1-a, anticorps zfp36l1-b, anticorps ZFP36 ring finger protein like 2, anticorps zinc finger protein 36, C3H type-like 2, anticorps ZFP36 ring finger protein-like 2 S homeolog, anticorps ZFP36 ring finger protein-like 2 L homeolog, anticorps ZFP36 ring finger protein-like 2, anticorps zinc finger protein 36, C3H type-like 1a, anticorps ZFP36 ring finger protein-like 1 L homeolog, anticorps ZFP36L2, anticorps Zfp36l2, anticorps zfp36l2, anticorps zfp36l2.S, anticorps zfp36l2.L, anticorps zfp36l1a, anticorps zfp36l1.L

Sujet:

Description: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.

Gene: ZFP36L2

Poids moléculaire: 40 kDa

ID gène: 678

UniProt: P47974

Pathways: Stem Cell Maintenance