ZFP36L2 anticorps (AA 219-321)

N° du produit ABIN7160264

Détail du produit anti-ZFP36L2 anticorps

Antigène: ZFP36L2 (Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2))

Épitope: AA 219-321

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZFP36L2 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Rat

Purification: >95%, Protein G purified

Immunogène: Recombinant Human mRNA decay activator protein ZFP36L2 protein (219-321AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ZFP36L2

Antigène: ZFP36L2 (Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2))

Autre désignation: ZFP36L2 (ZFP36L2 Produits)

Synonymes: anticorps BRF2, anticorps ERF-2, anticorps ERF2, anticorps RNF162C, anticorps TIS11D, anticorps Brf2, anticorps Tis11d, anticorps fi22c11, anticorps wu:fi22c11, anticorps zgc:76924, anticorps ZFP36L2, anticorps XC3H-3, anticorps XC3H-3b, anticorps c3h-3, anticorps zfp36l2, anticorps brf2, anticorps erf-2, anticorps erf2, anticorps rnf162c, anticorps tis11d, anticorps cb198, anticorps cb480, anticorps fk89d11, anticorps id:ibd1247, anticorps sb:cb198, anticorps sb:cb480, anticorps wu:fb80h11, anticorps wu:fb92f07, anticorps wu:fk89d11, anticorps zfp36l1, anticorps zgc:153979, anticorps XC3H-2, anticorps berg36, anticorps brf1, anticorps c3h-2, anticorps cmg1, anticorps erf-1, anticorps erf1, anticorps rnf162b, anticorps tis11b, anticorps zfp36l1-a, anticorps zfp36l1-b, anticorps ZFP36 ring finger protein like 2, anticorps zinc finger protein 36, C3H type-like 2, anticorps ZFP36 ring finger protein-like 2 S homeolog, anticorps ZFP36 ring finger protein-like 2 L homeolog, anticorps ZFP36 ring finger protein-like 2, anticorps zinc finger protein 36, C3H type-like 1a, anticorps ZFP36 ring finger protein-like 1 L homeolog, anticorps ZFP36L2, anticorps Zfp36l2, anticorps zfp36l2, anticorps zfp36l2.S, anticorps zfp36l2.L, anticorps zfp36l1a, anticorps zfp36l1.L

Sujet:

Background: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3\\\'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3\\\'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.

Aliases: BRF2 antibody, Butyrate response factor 2 antibody, C3H1 type-like 2 antibody, EGF response factor 2 antibody, EGF-response factor 2 antibody, ERF 2 antibody, ERF-2 antibody, ERF2 antibody, Protein TIS11D antibody, RNF162C antibody, TIS11D antibody, TISD_HUMAN antibody, ZFP36 like 2 antibody, ZFP36 ring finger protein like 2 antibody, ZFP36-like 2 antibody, Zfp36l2 antibody, Zinc finger protein 36 antibody, Zinc finger protein 36, C3H type like 1 antibody, zinc finger protein 36, C3H type like 2 antibody, Zinc finger protein 36, C3H1 type like 2 antibody, Zinc finger protein, C3H type, 36 like 2 antibody

UniProt: P47974

Pathways: Stem Cell Maintenance