SMARCA2 anticorps (C-Term)

N° du produit ABIN6260316

Détail du produit anti-SMARCA2 anticorps

Antigène: SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMARCA2 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: Brm Antibody detects endogenous levels of total Brm.

Homologie: Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Brm, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SMARCA2

Antigène: SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2))

Autre désignation: SMARCA2 (SMARCA2 Produits)

Synonymes: anticorps BAF190, anticorps BRM, anticorps NCBRS, anticorps SNF2, anticorps SNF2L2, anticorps SNF2LA, anticorps SWI2, anticorps Sth1p, anticorps hBRM, anticorps hSNF2a, anticorps brm, anticorps 2610209L14Rik, anticorps SNF2alpha, anticorps Snf2l2, anticorps brahma, anticorps psa-4, anticorps wu:fa56c07, anticorps wu:fi27f11, anticorps zgc:66238, anticorps Brahma, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 L homeolog, anticorps SMARCA2, anticorps smarca2.L, anticorps Smarca2, anticorps smarca2

Sujet:

Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Gene: SMARCA2

Poids moléculaire: 181 kDa

ID gène: 6595

UniProt: P51531