CDC34 anticorps (Internal Region)

N° du produit ABIN6260683

Détail du produit anti-CDC34 anticorps

Antigène: CDC34 (Cell Division Cycle 34 (CDC34))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDC34 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: CDC34 Antibody detects endogenous levels of total CDC34.

Homologie: Pig,Bovine,Sheep,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CDC34, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CDC34

Antigène: CDC34 (Cell Division Cycle 34 (CDC34))

Autre désignation: CDC34 (CDC34 Produits)

Synonymes: anticorps E2-CDC34, anticorps UBC3, anticorps UBCH3, anticorps UBE2R1, anticorps AI327276, anticorps e2-cdc34, anticorps ubc3, anticorps ube2r1, anticorps CDC34, anticorps DNA6, anticorps Ube2r2, anticorps zgc:55452, anticorps fb34h09, anticorps wu:fb34h09, anticorps wu:fe17e09, anticorps zgc:91847, anticorps cell division cycle 34, anticorps cell division cycle 34 L homeolog, anticorps SCF E2 ubiquitin-protein ligase catalytic subunit CDC34, anticorps SCF E2 ubiquitin-protein ligase catalytic subunit, anticorps cell division cycle 34 homolog (S. cerevisiae) a, anticorps cell division cycle 34 homolog (S. cerevisiae) b, anticorps CDC34, anticorps Cdc34, anticorps cdc34.L, anticorps cdc34, anticorps cdc34a, anticorps cdc34b

Sujet:

Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:22496338). Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes (PubMed:10329681, PubMed:10373550, PubMed:10871850, PubMed:11675391, PubMed:12037680, PubMed:15652359, PubMed:17461777, PubMed:17698585, PubMed:19112177, PubMed:19126550, PubMed:19945379, PubMed:20061386, PubMed:20347421).

Gene: CDC34

Poids moléculaire: 26 kDa

ID gène: 997

UniProt: P49427