CRBN anticorps

N° du produit ABIN6261020

Détail du produit anti-CRBN anticorps

Antigène: CRBN (Cereblon (CRBN))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRBN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: CRBN antibody detects endogenous levels of CRBN.

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CRBN.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur CRBN

Antigène: CRBN (Cereblon (CRBN))

Autre désignation: CRBN (CRBN Produits)

Synonymes: anticorps zgc:92404, anticorps mrt2a, anticorps F3N11.21, anticorps MRT2, anticorps MRT2A, anticorps 2610203G15Rik, anticorps 2900045O07Rik, anticorps AF229032, anticorps AW108261, anticorps piL, anticorps cereblon, anticorps ATP-dependent protease La (LON) domain protein, anticorps crbn, anticorps CRBN, anticorps AT2G25740, anticorps Crbn

Sujet:

Description: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.

Gene: CRBN

Poids moléculaire: 51-55 kDa

ID gène: 51185

UniProt: Q96SW2