SS18L1 anticorps

N° du produit ABIN6261030

Détail du produit anti-SS18L1 anticorps

Antigène: SS18L1 (Synovial Sarcoma Translocation Gene On Chromosome 18-Like 1 (SS18L1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SS18L1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: CREST antibody detects endogenous levels of CREST.

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CREST.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur SS18L1

Antigène: SS18L1 (Synovial Sarcoma Translocation Gene On Chromosome 18-Like 1 (SS18L1))

Autre désignation: CREST (SS18L1 Produits)

Synonymes: anticorps crest, anticorps CREST, anticorps LP2261, anticorps A230053O16Rik, anticorps SS18L1, nBAF chromatin remodeling complex subunit, anticorps synovial sarcoma translocation gene on chromosome 18-like 1, anticorps synovial sarcoma translocation gene on chromosome 18-like 1 S homeolog, anticorps SS18, nBAF chromatin remodeling complex subunit like 1, anticorps SS18L1, anticorps ss18l1, anticorps ss18l1.S, anticorps Ss18l1

Sujet:

Description: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).

Gene: SS18L1

Poids moléculaire: 50 kDa

ID gène: 26039

UniProt: O75177