CX3CL1 anticorps (Internal Region)

N° du produit ABIN6261117

Détail du produit anti-CX3CL1 anticorps

Antigène: CX3CL1 (Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CX3CL1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: CX3CL1 Antibody detects endogenous levels of total CX3CL1.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CX3CL1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CX3CL1

Antigène: CX3CL1 (Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))

Autre désignation: CX3CL1 (CX3CL1 Produits)

Synonymes: anticorps ABCD3, anticorps CX3CL1, anticorps DKFZp459K117, anticorps Cx3c, anticorps Scyd1, anticorps ABCD-3, anticorps C3Xkine, anticorps CXC3, anticorps CXC3C, anticorps NTN, anticorps NTT, anticorps SCYD1, anticorps fractalkine, anticorps neurotactin, anticorps AB030188, anticorps AI848747, anticorps CX3C, anticorps Cxc3, anticorps D8Bwg0439e, anticorps ATP binding cassette subfamily D member 3, anticorps C-X3-C motif chemokine ligand 1, anticorps chemokine (C-X3-C motif) ligand 1, anticorps ABCD3, anticorps CX3CL1, anticorps Cx3cl1, anticorps Abcd3

Sujet:

Description: Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350).

Gene: CX3CL1

Poids moléculaire: 90-100 kDa

ID gène: 6376

UniProt: P78423

Pathways: Synaptic Membrane