EIF2A anticorps (Eukaryotic Translation Initiation Factor 2A, 65kDa)

Details for Product anti-EIF2A Antibody No. ABIN6261472
Antigène
  • ATEIF2-A2
  • EIF2-A2
  • eukaryotic translation initiation factor 2 alpha subunit
  • EIF-2A
  • MST089
  • MSTP004
  • MSTP089
  • D030048D22
  • D3Ertd194e
  • im:7145971
  • zgc:110460
  • DDBDRAFT_0185936
  • DDBDRAFT_0234177
  • DDB_0185936
  • DDB_0234177
  • Eif2a
  • eif2a
  • eif2alpha
  • EIF2A
  • CG9946
  • Dmel\\CG9946
  • Eif2alpha
  • IF2A_DROME
  • M(1)14C
  • M(1)19-153
  • M(1)8e3-10
  • deIF2alpha
  • eIF-2
  • eIF-2 a
  • eIF-2 alpha
  • eIF2 alpha
  • eIF2-alpha
  • eIF2a
  • eIF2alpha
  • eiF-2alpha
  • elF2alpha
  • l(1)14Cf
  • l(1)19-153
  • eukaryotic translation initiation factor 2 alpha subunit
  • eukaryotic translation initiation factor 2A
  • eukaryotic translation initiation factor 2A, 65kDa
  • eukaryotic translation initiation factor 2A S homeolog
  • eukaryotic translation initiation factor
  • eukaryotic translation Initiation Factor 2alpha
  • EIF2 ALPHA
  • EIF2A
  • Eif2a
  • eif2a
  • eIF2a
  • eif2a.S
  • eif2A
  • eIF-2alpha
Reactivité
Humain, Souris, Rat (Rattus)
155
89
82
8
5
3
2
2
1
1
1
1
1
1
Hôte
Lapin
133
23
Clonalité
Polyclonal
Conjugué
Cet anticorp EIF2A est non-conjugé
7
5
5
5
5
4
4
3
3
2
2
2
2
2
2
2
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
105
82
47
32
31
20
15
7
4
4
1
1
Options
Immunogène A synthesized peptide derived from human eIF2 alpha
Isotype IgG
Specificité EIF2 alpha Antibody detects endogenous levels of total eIF2 alpha
 Réactivité croisée Humain, Souris, Rat (Rattus)
Purification The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Plasmids, Primers & others Plasmids, Primers & others EIF2A products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation eIF2 alpha (EIF2A Antibody Extrait)
Sujet

Description: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Gene: EIF2S1

Poids moléculaire 38kDa
ID gène 1965
UniProt P05198
Pathways Ribonucleoprotein Complex Subunit Organization, ER-Nucleus Signaling, Hepatitis C, Methionine Biosynthetic Process, Ribosome Assembly
Indications d'application WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20 °C.Stable for 12 months from date of receipt
Date de péremption 12 months
Images (Fournisseur)
Western Blotting (WB) image for anti-Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) antibody (ABIN6261472) Western blot analysis of eIF2 alpha expression in IFN-α treated K562 whole cell lysat...
Western Blotting (WB) image for anti-Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) antibody (ABIN6261472) MCF-7 and MDA-MB-231 cells were treated with the indicated concentrations of BA for 2...
Immunohistochemistry (IHC) image for anti-Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) antibody (ABIN6261472) ABIN6269092 at 1/100 staining Human liver tissue by IHC-P. The sample was formaldehyd...
Immunofluorescence (fixed cells) (IF/ICC) image for anti-Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) antibody (ABIN6261472) ABIN6269092 staining K562 by IF/ICC. The sample were fixed with PFA and permeabilized...
Produit citée dans: Cai, Zheng, Gu, Wang, Wang, Yang, Zhang, Wang, Fu, Wang: "Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78." dans: Cell death & disease, Vol. 9, Issue 6, pp. 636, 2018 (PubMed).

Liu, Shen, Wang, Liu, Zheng, Luo: "EndophilinA2 protects against angiotensin II-induced cardiac hypertrophy by inhibiting angiotensin II type 1 receptor trafficking in neonatal rat cardiomyocytes." dans: Journal of cellular biochemistry, 2018 (PubMed).

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