EPH Receptor A4 anticorps (Internal Region)

N° du produit ABIN6261563

Détail du produit anti-EPH Receptor A4 anticorps

Antigène: EPH Receptor A4 (EPHA4)

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor A4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: EPHA4 Antibody detects endogenous levels of total EPHA4.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human EPHA4, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur EPH Receptor A4

Antigène: EPH Receptor A4 (EPHA4)

Autre désignation: EPHA4 (EPHA4 Produits)

Synonymes: anticorps HEK8, anticorps SEK, anticorps TYRO1, anticorps RGD1560587, anticorps ephe, anticorps EPHA4, anticorps Ci-Eph1, anticorps sek, anticorps hek8, anticorps rtk1, anticorps tyr01, anticorps 2900005C20Rik, anticorps AI385584, anticorps Cek8, anticorps Hek8, anticorps Sek, anticorps Sek1, anticorps Tyro1, anticorps rb, anticorps XEpha4, anticorps sek-1, anticorps epha4, anticorps pag, anticorps EphA4, anticorps apha3, anticorps ek2, anticorps epha3, anticorps sb:cb246, anticorps zek2, anticorps zgc:109882, anticorps EPH receptor A4, anticorps Eph receptor A4, anticorps ephrin receptor epsilon, anticorps EPH receptor A4 S homeolog, anticorps EPH receptor A4 L homeolog, anticorps eph receptor A4a, anticorps EPHA4, anticorps Epha4, anticorps ephe, anticorps epha4, anticorps epha4.S, anticorps epha4.L, anticorps epha4a

Sujet:

Description: Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.

Gene: EPHA4

Poids moléculaire: 110 kDa

ID gène: 2043

UniProt: P54764

Pathways: Signalisation RTK