GDF6 anticorps (C-Term)

N° du produit ABIN6261929

Détail du produit anti-GDF6 anticorps

Antigène: GDF6 (Growth Differentiation Factor 6 (GDF6))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GDF6 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: GDF6 Antibody detects endogenous levels of total GDF6.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human GDF6, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur GDF6

Antigène: GDF6 (Growth Differentiation Factor 6 (GDF6))

Autre désignation: GDF6 (GDF6 Produits)

Synonymes: anticorps BMP13, anticorps CDMP2, anticorps KFM, anticorps KFS, anticorps KFS1, anticorps KFSL, anticorps LCA17, anticorps MCOP4, anticorps MCOPCB6, anticorps SCDO4, anticorps SGM1, anticorps GDF16, anticorps gdf16, anticorps CDMP-2, anticorps gdf6, anticorps rdr, anticorps sb:cb278, anticorps bmp13, anticorps cdmp2, anticorps gdf-6, anticorps kfs, anticorps kfsl, anticorps sgm1, anticorps growth differentiation factor 6, anticorps growth differentiation factor 6a, anticorps growth differentiation factor 6 S homeolog, anticorps GDF6, anticorps Gdf6, anticorps gdf6, anticorps gdf6a, anticorps gdf6.S

Sujet:

Description: Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres. Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity).

Gene: GDF6

Poids moléculaire: 51 kDa

ID gène: 392255

UniProt: Q6KF10