HBXIP anticorps (Internal Region)

N° du produit ABIN6262158

Détail du produit anti-HBXIP anticorps

Antigène: HBXIP (Hepatitis B Virus X-Interacting Protein (HBXIP))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HBXIP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: HBXIP Antibody detects endogenous levels of total HBXIP.

Homologie: Pig,Bovine,Horse,Rabbit,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human HBXIP, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur HBXIP

Antigène: HBXIP (Hepatitis B Virus X-Interacting Protein (HBXIP))

Autre désignation: LAMTOR5 (HBXIP Produits)

Synonymes: anticorps HBXIP, anticorps xip, anticorps XIP, anticorps 1110003H18Rik, anticorps Hbxip, anticorps late endosomal/lysosomal adaptor, MAPK and MTOR activator 5, anticorps Hepatitis B virus X-interacting protein, anticorps LAMTOR5, anticorps xip, anticorps Lamtor5

Classe de substances: Viral Protein

Sujet:

Description: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Gene: LAMTOR5

Poids moléculaire: 22 kDa

ID gène: 10542

UniProt: O43504

Pathways: Signalisation PI3K-Akt, Regulation of Cell Size