INPPL1 anticorps (Internal Region)
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- Antigène Voir toutes INPPL1 Anticorps
- INPPL1 (Inositol Polyphosphate Phosphatase-Like 1 (INPPL1))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp INPPL1 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- INPPL1 Antibody detects endogenous levels of total INPPL1.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human INPPL1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product INPPL1 Anticorps primaire
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- Indications d'application
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- INPPL1 (Inositol Polyphosphate Phosphatase-Like 1 (INPPL1))
- Autre désignation
- INPPL1 (INPPL1 Produits)
- Synonymes
- anticorps OPSMD, anticorps SHIP2, anticorps 51C, anticorps Ship2, anticorps inppl1, anticorps si:bz46j2.7, anticorps si:rp71-46j2.7, anticorps INPPL1, anticorps fc58a04, anticorps wu:fc58a04, anticorps zgc:198309, anticorps inositol polyphosphate phosphatase like 1, anticorps inositol polyphosphate phosphatase-like 1, anticorps inositol polyphosphate phosphatase-like 1b, anticorps phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B, anticorps inositol polyphosphate phosphatase-like 1a, anticorps INPPL1, anticorps Inppl1, anticorps inppl1b, anticorps LOC100180571, anticorps inppl1a
- Sujet
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Description: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity. Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1. In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification.
Gene: INPPL1
- Poids moléculaire
- 139kDa
- ID gène
- 3636
- UniProt
- O15357
- Pathways
- Platelet-derived growth Factor Receptor Signaling
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