KCNQ1 anticorps (C-Term)
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- Antigène Voir toutes KCNQ1 Anticorps
- KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp KCNQ1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Specificité
- KCNQ1 Antibody detects endogenous levels of total KCNQ1.
- Homologie
- Horse,Rabbit,Dog,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human KCNQ1, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product KCNQ1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))
- Autre désignation
- KCNQ1 (KCNQ1 Produits)
- Synonymes
- anticorps ATFB1, anticorps ATFB3, anticorps JLNS1, anticorps KCNA8, anticorps KCNA9, anticorps KVLQT1, anticorps Kv1.9, anticorps Kv7.1, anticorps LQT, anticorps LQT1, anticorps RWS, anticorps SQT2, anticorps WRS, anticorps CG12215, anticorps CG12915, anticorps CG33135, anticorps DKCNQ, anticorps Dmel\\CG33135, anticorps dKCNQ, anticorps kcnq1, anticorps KCNQ1, anticorps kqt-3, anticorps kv7.1, anticorps Kvlqt1, anticorps KvLQT-1, anticorps kcnq1-A, anticorps xkvlqt1, anticorps zgc:158384, anticorps AW559127, anticorps Kcna9, anticorps KvLQT1, anticorps potassium voltage-gated channel subfamily Q member 1, anticorps KCNQ potassium channel, anticorps potassium voltage-gated channel, KQT-like subfamily, member 1, anticorps potassium channel, voltage gated KQT-like subfamily Q, member 1, anticorps voltage gated potassium channel subunit, anticorps potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog, anticorps potassium voltage-gated channel, subfamily Q, member 1, anticorps KCNQ1, anticorps KCNQ, anticorps kcnq1, anticorps Kcnq1, anticorps kcnq1.L
- Sujet
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Description: Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity) (PubMed:10646604). Associates with KCNE beta subunits that modulates current kinetics (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505, PubMed:19687231). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418). Also forms a heterotetramer with KCNQ5, has a voltage-gated potassium channel activity (PubMed:24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed:25037568).
Gene: KCNQ1
- Poids moléculaire
- 61kDa
- ID gène
- 3784
- UniProt
- P51787
- Pathways
- Negative Regulation of Hormone Secretion, Sensory Perception of Sound
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