GRIN2C anticorps (Internal Region)

N° du produit ABIN6263663

Détail du produit anti-GRIN2C anticorps

Antigène: GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRIN2C est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: NMDA epsilon 3 Antibody detects endogenous levels of total NMDA epsilon 3.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human NMDA epsilon 3, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur GRIN2C

Antigène: GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

Autre désignation: GRIN2C (GRIN2C Produits)

Synonymes: anticorps GRIN2C, anticorps NMDAR2C, anticorps il12rb2l, anticorps il-12rb2.b, anticorps nr2c, anticorps GluN2C, anticorps NR2C, anticorps glutamate ionotropic receptor NMDA type subunit 2C, anticorps interleukin 12 receptor, beta 2a, like, anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 2C S homeolog, anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 2C, anticorps glutamate receptor, ionotropic, NMDA2C (epsilon 3), anticorps GRIN2C, anticorps il12rb2l, anticorps grin2c.S, anticorps grin2c, anticorps Grin2c

Sujet:

Description: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:26875626). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).

Gene: GRIN2C

Poids moléculaire: 134 kDa

ID gène: 2905

UniProt: Q14957

Pathways: Synaptic Membrane