NR1H2 anticorps (Internal Region)

N° du produit ABIN6263714

Détail du produit anti-NR1H2 anticorps

Antigène: NR1H2 (Nuclear Receptor Subfamily 1, Group H, Member 2 (NR1H2))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NR1H2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: NR1H2 Antibody detects endogenous levels of total NR1H2.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human NR1H2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur NR1H2

Antigène: NR1H2 (Nuclear Receptor Subfamily 1, Group H, Member 2 (NR1H2))

Autre désignation: NR1H2 (NR1H2 Produits)

Synonymes: anticorps NR1H2, anticorps lxr-b, anticorps lxrb, anticorps ner, anticorps ner-i, anticorps rip15, anticorps unr, anticorps DKFZp468A0622, anticorps AI194859, anticorps LXR, anticorps LXRB, anticorps LXRbeta, anticorps NER1, anticorps OR-1, anticorps RIP15, anticorps UR, anticorps Unr, anticorps Unr2, anticorps LXR-b, anticorps NER, anticorps NER-I, anticorps UNR, anticorps nuclear receptor subfamily 1 group H member 2, anticorps nuclear receptor subfamily 1, group H, member 2, anticorps nuclear receptor subfamily 1 group H member 2 L homeolog, anticorps NR1H2, anticorps nr1h2, anticorps Nr1h2, anticorps nr1h2.L

Sujet:

Description: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8, DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).

Gene: NR1H2

Poids moléculaire: 51 kDa

ID gène: 7376

UniProt: P55055

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Nuclear Hormone Receptor Binding