FIP200 anticorps
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- Antigène Voir toutes FIP200 (RB1CC1) Anticorps
- FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FIP200 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificité
- RB1CC1 antibody detects endogenous levels of RB1CC1.
- Réactivité croisée
- Humain, Souris, Rat (Rattus)
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human RB1CC1.
- Isotype
- IgG
- Top Product
- Discover our top product RB1CC1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C.Stable for 12 months from date of receipt
- Date de péremption
- 12 months
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- Antigène
- FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))
- Autre désignation
- RB1CC1 (RB1CC1 Produits)
- Synonymes
- anticorps DKFZp459E2330, anticorps CC1, anticorps FIP200, anticorps 2900055E04Rik, anticorps 5930404L04Rik, anticorps Cc1, anticorps LaXp180, anticorps RB1 inducible coiled-coil 1, anticorps RB1 inducible coiled-coil 1 L homeolog, anticorps RB1-inducible coiled-coil 1, anticorps RB1CC1, anticorps rb1cc1.L, anticorps rb1cc1, anticorps Rb1cc1
- Sujet
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Description: Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).
Gene: RB1CC1
- Poids moléculaire
- 200 kDa
- ID gène
- 9821
- UniProt
- Q8TDY2
- Pathways
- Regulation of Cell Size, Autophagy
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