S100A12 anticorps

N° du produit ABIN6264899

Détail du produit anti-S100A12 anticorps

Antigène: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp S100A12 est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Specificité: S100A12 Antibody detects endogenous levels of total S100A12

Réactivité croisée: Humain, Souris

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human S100A12

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur S100A12

Antigène: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Autre désignation: S100A12 (S100A12 Produits)

Synonymes: anticorps CAAF1, anticorps CAGC, anticorps CGRP, anticorps ENRAGE, anticorps MRP-6, anticorps MRP6, anticorps p6, anticorps CO-AG, anticorps EN-RAGE, anticorps S100 calcium binding protein A12, anticorps protein S100-A12, anticorps S100A12, anticorps LOC101103771

Sujet:

Description: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases, MMP2, MMP3 and MMP9 by chelating Zn2+ from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.

Gene: S100A12

Poids moléculaire: 10kDa

ID gène: 6283

UniProt: P80511

Pathways: Toll-Like Receptors Cascades, S100 Proteins