Sestrin 2 anticorps

N° du produit ABIN6265016

Détail du produit anti-Sestrin 2 anticorps

Antigène: Sestrin 2 (SESN2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sestrin 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Sestrin 2 antibody detects endogenous levels of Sestrin 2.

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Sestrin 2.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur Sestrin 2

Antigène: Sestrin 2 (SESN2)

Autre désignation: Sestrin 2 (SESN2 Produits)

Synonymes: anticorps HI95, anticorps SES2, anticorps SEST2, anticorps Ses2, anticorps MGC81239, anticorps SESN2, anticorps sestrin-2, anticorps hi95, anticorps ses2, anticorps sest2, anticorps Sestrin-2, anticorps RGD1566319, anticorps sestrin 2, anticorps sestrin 2 L homeolog, anticorps SESN2, anticorps Sesn2, anticorps sesn2.L, anticorps sesn2

Sujet:

Description: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821).

Gene: SESN2

Poids moléculaire: 54-60 kDa

ID gène: 83667

UniProt: P58004