SLC3A2 anticorps (Internal Region)

N° du produit ABIN6265132

Détail du produit anti-SLC3A2 anticorps

Antigène: SLC3A2 (Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2))

Épitope: Internal Region

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC3A2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: SLC3A2 Antibody detects endogenous levels of total SLC3A2.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SLC3A2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SLC3A2

Antigène: SLC3A2 (Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2))

Autre désignation: SLC3A2 (SLC3A2 Produits)

Synonymes: anticorps 4F2, anticorps 4F2HC, anticorps 4T2HC, anticorps CD98, anticorps CD98HC, anticorps MDU1, anticorps NACAE, anticorps Mdu1, anticorps MGC53951, anticorps slc3a2, anticorps MGC53965, anticorps SLC3A2, anticorps AI314110, anticorps Cd98, anticorps Ly-10, anticorps Ly-m10, anticorps Ly10, anticorps Mgp-2hc, anticorps fc65h12, anticorps wu:fc65h12, anticorps id:ibd1327, anticorps sb:cb519, anticorps wu:fe14a07, anticorps wu:fq18d12, anticorps zgc:55813, anticorps solute carrier family 3 member 2, anticorps solute carrier family 3 (amino acid transporter heavy chain), member 2 L homeolog, anticorps solute carrier family 3 (amino acid transporter heavy chain), member 2 S homeolog, anticorps solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2, anticorps solute carrier family 3 (amino acid transporter heavy chain), member 2a, anticorps solute carrier family 3 (amino acid transporter heavy chain), member 2b, anticorps SLC3A2, anticorps Slc3a2, anticorps slc3a2.L, anticorps slc3a2.S, anticorps slc3a2a, anticorps slc3a2b

Sujet:

Description: Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. When associated with LAPTM4B, recruits SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567).

Gene: SLC3A2

Poids moléculaire: 67kDa

ID gène: 6520

UniProt: P08195