SMURF1 anticorps (Internal Region)

N° du produit ABIN6265195

Détail du produit anti-SMURF1 anticorps

Antigène: SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMURF1 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: SMURF1 Antibody detects endogenous levels of total SMURF1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SMURF1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SMURF1

Antigène: SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1))

Autre désignation: SMURF1 (SMURF1 Produits)

Synonymes: anticorps 4930431E10Rik, anticorps mKIAA1625, anticorps RGD1309707, anticorps SMAD specific E3 ubiquitin protein ligase 1, anticorps E3 ubiquitin-protein ligase SMURF1, anticorps SMAD specific E3 ubiquitin protein ligase 1 L homeolog, anticorps SMURF1, anticorps LOC100540915, anticorps smurf1, anticorps Smurf1, anticorps smurf1.L

Sujet:

Description: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Gene: SMURF1

Poids moléculaire: 86 kDa

ID gène: 57154

UniProt: Q9HCE7

Pathways: Regulation of Cell Size