TSHZ3 anticorps (Internal Region)

N° du produit ABIN6265771

Détail du produit anti-TSHZ3 anticorps

Antigène: TSHZ3 (ZNF537) (Zinc Finger Protein 537 (ZNF537))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSHZ3 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: TSH3 Antibody detects endogenous levels of total TSH3.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TSH3, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur TSHZ3

Antigène: TSHZ3 (ZNF537) (Zinc Finger Protein 537 (ZNF537))

Autre désignation: TSHZ3 (ZNF537 Produits)

Synonymes: anticorps ZNF537, anticorps A630038G13Rik, anticorps Tsh3, anticorps Zfp537, anticorps mKIAA1474, anticorps teashirt3, anticorps TSH3, anticorps teashirt zinc finger homeobox 3, anticorps teashirt zinc finger family member 3, anticorps TSHZ3, anticorps Tshz3

Sujet:

Description: Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity).

Gene: TSHZ3

Poids moléculaire: 119 kDa

ID gène: 57616

UniProt: Q63HK5

Pathways: Regulation of Muscle Cell Differentiation