U2AF2 anticorps (Internal Region)

N° du produit ABIN6265832

Détail du produit anti-U2AF2 anticorps

Antigène: U2AF2 (U2AF59) (U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp U2AF2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: U2AF2 Antibody detects endogenous levels of total U2AF2.

Homologie: Pig,Bovine,Horse,Sheep,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human U2AF2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur U2AF2

Antigène: U2AF2 (U2AF59) (U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59))

Autre désignation: U2AF2 (U2AF59 Produits)

Synonymes: anticorps U2AF65, anticorps 65kDa, anticorps u2af65, anticorps U2AF2, anticorps DDBDRAFT_0186947, anticorps DDBDRAFT_0233353, anticorps DDB_0186947, anticorps DDB_0233353, anticorps zgc:110115, anticorps U2 small nuclear RNA auxiliary factor 2, anticorps U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2, anticorps U2 small nuclear RNA auxiliary factor 2 S homeolog, anticorps RNA recognition motif-containing protein RRM, anticorps Splicing factor U2AF 65 kDa subunit, anticorps U2 small nuclear RNA auxiliary factor 2a, anticorps U2AF2, anticorps U2af2, anticorps u2af2.S, anticorps u2af2, anticorps u2af2a

Sujet:

Description: Plays a role in pre-mRNA splicing and 3'-end processing (PubMed:17024186). By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186).

Gene: U2AF2

Poids moléculaire: 53kDa

ID gène: 11338

UniProt: P26368