VAMP8 anticorps (Internal Region)

N° du produit ABIN6265946

Détail du produit anti-VAMP8 anticorps

Antigène: VAMP8 (Vesicle-Associated Membrane Protein 8 (Endobrevin) (VAMP8))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VAMP8 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: VAMP8 Antibody detects endogenous levels of total VAMP8.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human VAMP8, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur VAMP8

Antigène: VAMP8 (Vesicle-Associated Membrane Protein 8 (Endobrevin) (VAMP8))

Autre désignation: VAMP8 (VAMP8 Produits)

Synonymes: anticorps vamp8, anticorps EDB, anticorps VAMP-8, anticorps AU041171, anticorps Edb, anticorps endobrevin, anticorps wu:fa18d07, anticorps zgc:56588, anticorps vesicle associated membrane protein 8, anticorps vesicle-associated membrane protein 8 (endobrevin), anticorps vesicle-associated membrane protein 8, anticorps vamp8, anticorps VAMP8, anticorps Vamp8

Sujet:

Description: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity).

Gene: VAMP8

Poids moléculaire: 15 kDa

ID gène: 8673

UniProt: Q9BV40