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VPS11 anticorps (Internal Region)

VPS11 Reactivité: Humain, Souris, Rat WB, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6265995
  • Antigène Voir toutes VPS11 Anticorps
    VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))
    Épitope
    • 8
    • 8
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 31
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 27
    • 3
    • 1
    Lapin
    Clonalité
    • 28
    • 3
    Polyclonal
    Conjugué
    • 21
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp VPS11 est non-conjugé
    Application
    • 29
    • 19
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    VPS11 Antibody detects endogenous levels of total VPS11.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human VPS11, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product VPS11 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))
    Autre désignation
    VPS11 (VPS11 Produits)
    Synonymes
    anticorps zgc:112329, anticorps ATVPS11, anticorps F5G3.7, anticorps F5G3_7, anticorps vacuolar protein sorting 11, anticorps DDBDRAFT_0204454, anticorps DDBDRAFT_0234135, anticorps DDB_0204454, anticorps DDB_0234135, anticorps end1, anticorps pep5, anticorps hvps11, anticorps rnf108, anticorps 1200011A11Rik, anticorps END1, anticorps PEP5, anticorps RNF108, anticorps hVPS11, anticorps VPS11, CORVET/HOPS core subunit, anticorps vacuolar protein sorting 11, anticorps vacuolar protein sorting protein 11, anticorps VPS11, CORVET/HOPS core subunit S homeolog, anticorps Vacuolar peripheral membrane protein similar to S. cerevisiae PEP5 (YMR231W); C terminus is almost identical to nonallelic CaP19.1278, anticorps 7-fold repeat in clathrin and VPS proteins repeat-containing protein, anticorps vacuolar protein sorting-associated protein 11 homolog, anticorps VPS11 CORVET/HOPS core subunit, anticorps VPS11, anticorps vps11, anticorps MCYG_02909, anticorps vps11.S, anticorps LOC100632536, anticorps Vps11
    Sujet

    Description: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).

    Gene: VPS11

    Poids moléculaire
    108-112 kDa
    ID gène
    55823
    UniProt
    Q9H270
    Pathways
    SARS-CoV-2 Protein Interactome
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