VPS16 anticorps (Internal Region)

N° du produit ABIN6265996

Détail du produit anti-VPS16 anticorps

Antigène: VPS16 (Vacuolar Protein Sorting-Associated Protein 16 Homolog (VPS16))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS16 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: VPS16 Antibody detects endogenous levels of total VPS16.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human VPS16, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur VPS16

Antigène: VPS16 (Vacuolar Protein Sorting-Associated Protein 16 Homolog (VPS16))

Autre désignation: VPS16 (VPS16 Produits)

Synonymes: anticorps 1810074M16Rik, anticorps hVPS16, anticorps VPS16A, anticorps vacuolar protein sorting protein 16, anticorps Vacuolar protein sorting-associated protein 16 homolog, anticorps VSP16 CORVET/HOPS core subunit, anticorps VPS16, CORVET/HOPS core subunit, anticorps vacuolar protein sorting 16 homolog (S. cerevisiae), anticorps VPS16 CORVET/HOPS core subunit, anticorps Tc00.1047053506367.60, anticorps Tc00.1047053508355.200, anticorps vps-16, anticorps Vps16, anticorps VPS16

Sujet:

Description: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for recruitment of VPS33A to the HOPS complex (PubMed:23901104). Required for fusion of endosomes and autophagosomes with lysosomes, the function is dependent on its association with VPS33A but not VPS33B (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).

Gene: VPS16

Poids moléculaire: 95 kDa

ID gène: 64601

UniProt: Q9H269