VPS16 anticorps (AA 7-89)

N° du produit ABIN7175666

Détail du produit anti-VPS16 anticorps

Antigène: VPS16 (Vacuolar Protein Sorting-Associated Protein 16 Homolog (VPS16))

Épitope: AA 7-89

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS16 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Rat

Purification: >95%, Protein G purified

Immunogène: Recombinant Human VPS16 protein (7-89AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur VPS16

Antigène: VPS16 (Vacuolar Protein Sorting-Associated Protein 16 Homolog (VPS16))

Autre désignation: VPS16 (VPS16 Produits)

Synonymes: anticorps 1810074M16Rik, anticorps hVPS16, anticorps VPS16A, anticorps vacuolar protein sorting protein 16, anticorps Vacuolar protein sorting-associated protein 16 homolog, anticorps VSP16 CORVET/HOPS core subunit, anticorps VPS16, CORVET/HOPS core subunit, anticorps vacuolar protein sorting 16 homolog (S. cerevisiae), anticorps VPS16 CORVET/HOPS core subunit, anticorps Tc00.1047053506367.60, anticorps Tc00.1047053508355.200, anticorps vps-16, anticorps Vps16, anticorps VPS16

Sujet:

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for recruitment of VPS33A to the HOPS complex (PubMed:23901104). Required for fusion of endosomes and autophagosomes with lysosomes, the function is dependent on its association with VPS33A but not VPS33B (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).

Aliases: Vacuolar protein sorting-associated protein 16 homolog (hVPS16), VPS16

UniProt: Q6GMQ7