WRAP53 anticorps (Internal Region)

N° du produit ABIN6266051

Détail du produit anti-WRAP53 anticorps

Antigène: WRAP53 (WD Repeat Containing, Antisense To TP53 (WRAP53))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WRAP53 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: WRAP53 Antibody detects endogenous levels of total WRAP53.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human WRAP53, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur WRAP53

Antigène: WRAP53 (WD Repeat Containing, Antisense To TP53 (WRAP53))

Autre désignation: WRAP53 (WRAP53 Produits)

Synonymes: anticorps DKCB3, anticorps TCAB1, anticorps WDR79, anticorps Wdr79, anticorps BC021790, anticorps WD repeat containing antisense to TP53, anticorps WD repeat containing, antisense to TP53, anticorps WD repeat containing, antisense to Trp53, anticorps WRAP53, anticorps Wrap53

Sujet:

Description: Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level, it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.

Gene: WRAP53

Poids moléculaire: 72-75 kDa

ID gène: 55135

UniProt: Q9BUR4

Pathways: Telomere Maintenance