AIRE anticorps (Ser156)

N° du produit ABIN6280595

Détail du produit anti-AIRE anticorps

Antigène: AIRE (Autoimmune Regulator (AIRE))

Épitope: AA 100-180, Ser156

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AIRE est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: Rabbit polyclonal to AIRE-1.

Specificité: AIRE-1 Polyclonal Antibody detects endogenous levels of AIRE-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human AIRE-1 around the non-phosphorylation site of S156.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
ELISA 1:5000

Commentaires:

Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. In secondary lymphoid organs, expressed in a discrete population of bone marrow-derived toleregenic antigen presenting cells (APCs) called extrathymic AIRE expressing cells (eTAC)(at protein level) . Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur AIRE

Antigène: AIRE (Autoimmune Regulator (AIRE))

Autre désignation: AIRE-1 (AIRE Produits)

Synonymes: anticorps AIRE1, anticorps APECED, anticorps APS1, anticorps APSI, anticorps PGA1, anticorps autoimmune regulator, anticorps autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy), anticorps AaeL_AAEL013794, anticorps CpipJ_CPIJ001208, anticorps CpipJ_CPIJ001209, anticorps AIRE, anticorps Aire

Poids moléculaire: 50 kDa

ID gène: 326

UniProt: O43918

Pathways: Chromatin Binding