MARK1/2/3/4 anticorps (AA 150-230)
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- Antigène Tous les produits MARK1/2/3/4
- MARK1/2/3/4 (MAP/microtubule Affinity-Regulating Kinase 1/2/3/4 (MARK1/2/3/4))
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Épitope
- AA 150-230
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Reactivité
- Humain, Souris, Rat, Singe
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MARK1/2/3/4 est non-conjugé
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Application
- ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Fonction
- MARK1/2/3/4 is a protein encoded by the MARK1 gene which is approximately 89 kDa. MARK1/2/3/4 is localised to the cell membrane and cytoplasm. It is involved in cytoplasm signalling and glucose/energy metabolism. It plays a role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1/2/3/4 is highly expressed in the heart, skeletal muscle, brain and foetal kidney. Mutations in the MARK1 gene may result in Alzheimer disease. STJ94015 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of MARK1/2/3/4 protein.
- Specificité
- MARK1/2/3/4 Polyclonal Antibody detects endogenous levels of MARK1/2/3/4 protein.
- Attributs du produit
- Rabbit polyclonal to MARK1/2/3/4.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogène
- Synthesized peptide derived from human MARK1/2/3/4 around the non-phosphorylation site of T215.
- Isotype
- IgG
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- Indications d'application
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WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000 - Commentaires
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Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Antigène
- MARK1/2/3/4 (MAP/microtubule Affinity-Regulating Kinase 1/2/3/4 (MARK1/2/3/4))
- Autre désignation
- MARK1/2/3/4 (MARK1/2/3/4 Produits)
- Poids moléculaire
- 89 kDa
- ID gène
- 4139
- UniProt
- Q9P0L2
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