Caspase-8 p18 anticorps (Cleaved-Ser217, Internal Region)
-
- Antigène Tous les produits Caspase-8 p18
- Caspase-8 p18 (Caspase 8 Subunit P18)
- Épitope
- AA 170-250, Cleaved-Ser217, Internal Region
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp Caspase-8 p18 est non-conjugé
- Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Fonction
- Caspase-8 is a protein encoded by the CASP8 gene which is approximately 55,3 kDa. Caspase-8 is localised to the cytoplasm and is involved in the TNFR1 pathway, dimerization of procaspase-8 , activated TLR4 signalling, apoptosis signalling and toll-like receptor signalling pathways. This protein falls under the cysteine-aspartic acid protease family. It pays a role in the programmed cell death induced by Fas and various apoptotic stimuli. Caspase-8 isoform 1, 5 and 7 are expressed in a wide variety of tissues. Mutations in the CASP8 gene may result in a caspase-8 deficiency. STJ97641 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.This polyclonal antibody detects endogenous levels of fragment of activated caspase-8 p18 protein resulting from cleavage adjacent to S217.
- Specificité
- Cleaved-Caspase-8 p18 (S217) Polyclonal Antibody detects endogenous levels of Cleaved-Caspase-8 p18 (S217) protein.
- Attributs du produit
- Rabbit polyclonal to Cleaved-Caspase-8 p18 (S217).
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogène
- Synthesized peptide derived from human Cleaved-Caspase-8 p18 (S217)
- Isotype
- IgG
-
-
- Indications d'application
-
WB 1:500-1:2000
ELISA 1:10000 - Commentaires
-
Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C, and avoid repeat freeze-thaw cycles.
-
- Antigène
- Caspase-8 p18 (Caspase 8 Subunit P18)
- Autre désignation
- Caspase-8 p18 (Caspase-8 p18 Produits)
- Synonymes
- anticorps ALPS2B, anticorps CAP4, anticorps Casp-8, anticorps FLICE, anticorps MACH, anticorps MCH5, anticorps CASP-8, anticorps Mch5, anticorps caspase 8, anticorps CASP8, anticorps Casp8
- ID gène
- 841
- UniProt
- Q14790
-