SNAIL anticorps (AA 190-270)

N° du produit ABIN6281922

Détail du produit anti-SNAIL anticorps

Antigène: SNAIL (SNAI1)

Épitope: AA 190-270

Reactivité: Humain, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNAIL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: SNAI 1 is a protein encoded by the SNAI1 gene which is approximately 29 kDa. SNAI 1 is localised to the cytoplasm and nucleus. It is involved in the development HGF signalling pathway and embryonic and induced pluripotent stem cell differentiation pathways and lineage-specific markers. It plays a role in the induction of the epithelial to mesenchymal transition, formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. It binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A, causes a decrease in dimethylated H3K4 levels and represses transcription. SNAI 1 is expressed in a variety of tissues with the highest expression in kidney. Mutations in the SNAI1 gene may result in cercarial dermatitis and fasciolopsiasis. STJ95716 was affinity purified. This poly clonal antibody binds SNAI 1.

Specificité: SNAI 1 Polyclonal Antibody detects endogenous levels of SNAI 1 protein.

Attributs du produit: Rabbit polyclonal to SNAI 1.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human SNAI 1 around the non-phosphorylation site of S246.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000

Commentaires:

Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur SNAIL

Antigène: SNAIL (SNAI1)

Autre désignation: SNAI 1 (SNAI1 Produits)

Synonymes: anticorps SLUGH2, anticorps SNA, anticorps SNAH, anticorps SNAIL, anticorps SNAIL1, anticorps dJ710H13.1, anticorps AI194338, anticorps Sna, anticorps Sna1, anticorps Snail, anticorps Snail1, anticorps SNAI1, anticorps BG:DS01845.1, anticorps CG3956, anticorps Dmel\\CG3956, anticorps Sco, anticorps br28, anticorps br29, anticorps l(2)35Db, anticorps l(2)br28, anticorps l(2)br29, anticorps l(3)br28, anticorps l35Db, anticorps sn, anticorps Xsnail, anticorps sna, anticorps snail1, anticorps xSna, anticorps Snai, anticorps sna2, anticorps snail2, anticorps cb643, anticorps sna-1, anticorps sna1, anticorps snai1, anticorps snail1a, anticorps zgc:109820, anticorps snail family transcriptional repressor 1, anticorps snail family zinc finger 1, anticorps snail homolog 1 (Drosophila), anticorps snail, anticorps zinc-finger transcription factor Snail, anticorps snail family zinc finger 1 S homeolog, anticorps protein escargot, anticorps transcription factor protein, anticorps snail zinc finger protein, anticorps snail family zinc finger 1b, anticorps snail family zinc finger 1a, anticorps SNAI1, anticorps Snai1, anticorps sna, anticorps snail, anticorps snai1.S, anticorps LOC410464, anticorps snai1b, anticorps snai1a

Poids moléculaire: 29 kDa

ID gène: 6615

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling