OTUB1 anticorps (Internal Region)

N° du produit ABIN6282055

Détail du produit anti-OTUB1 anticorps

Antigène: OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))

Épitope: AA 20-100, Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OTUB1 est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: Otubain-1 is a protein encoded by the OTUB1 gene which is approximately 31,3 kDa. Otubain-1 is localised to the cytoplasm and is involved in deubiquitination, metabolism of proteins, DNA damage and ovarian tumor domain proteases. Otubain-1 is a member of the ovarian tumor superfamily. It interacts with another ubiquitin protease and an E3 ubiquitin ligase whicj inhibits cytokine gene transcription in the immune system. It also plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of Lys-63-linked histone H2A and H2AX at DNA damage sites. Isoform 1 of otubain-1 is ubiquitously expressed while isoform 2 is expressed only in lymphoid tissues as well as peripheral blood mononuclear cells. Mutations in the OTUB1 gene may result in retinitis pigmentosa. STJ97632 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of otubain-1 protein.

Specificité: Otubain-1 Polyclonal Antibody detects endogenous levels of Otubain-1 protein.

Attributs du produit: Rabbit polyclonal to Otubain-1.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human Otubain-1

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
ELISA 1:10000

Commentaires:

Isoform 1 is ubiquitous. Isoform 2 is expressed only in lymphoid tissues such as tonsils, lymph nodes and spleen, as well as peripheral blood mononuclear cells.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur OTUB1

Antigène: OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))

Autre désignation: Otubain-1 (OTUB1 Produits)

Synonymes: anticorps OTB1, anticorps OTU1, anticorps AI850305, anticorps fa19h07, anticorps otub1, anticorps wu:fa19h07, anticorps zgc:92839, anticorps MGC131231, anticorps fb17f04, anticorps otub1l, anticorps wu:fb17f04, anticorps zgc:92685, anticorps OTU deubiquitinase, ubiquitin aldehyde binding 1, anticorps OTU domain, ubiquitin aldehyde binding 1, anticorps OTU deubiquitinase, ubiquitin aldehyde binding 1b, anticorps OTU deubiquitinase, ubiquitin aldehyde binding 1 L homeolog, anticorps similar to HSPC263, anticorps OTU deubiquitinase, ubiquitin aldehyde binding 1a, anticorps OTUB1, anticorps Otub1, anticorps otub1b, anticorps otub1.L, anticorps otub1, anticorps RGD1565010, anticorps otub1a

ID gène: 55611

UniProt: Q96FW1