Cytokeratin 19 anticorps (Internal Region)

N° du produit ABIN6282124

Détail du produit anti-Cytokeratin 19 anticorps

Antigène: Cytokeratin 19 (KRT19) (Keratin 19 (KRT19))

Épitope: AA 200-280, Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cytokeratin 19 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Cytokeratin 19 is a protein encoded by the KRT19 gene which is approximately 44,1 kDa. Cytokeratin 19 is localised to the cytosol. It is involved in cytoskeletal signalling, developmental biology and keratinization. This protein falls under the keratin family and consists of acidic proteins which are arranged in pairs of heterotypic keratin chains. It plays a role in the organization of myofibers and together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Cytokeratin 19 is expressed in basal keratinocytes in the deep outer root sheath of hair follicles. Mutations in the KRT19 gene may result in lung cancer and thyroid cancer. STJ92634 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Cytokeratin 19 protein.

Specificité: Cytokeratin 19 Polyclonal Antibody detects endogenous levels of Cytokeratin 19 protein.

Attributs du produit: Rabbit polyclonal to Cytokeratin 19.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human Cytokeratin 19

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000

Commentaires:

Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur Cytokeratin 19

Antigène: Cytokeratin 19 (KRT19) (Keratin 19 (KRT19))

Autre désignation: Cytokeratin 19 (KRT19 Produits)

Synonymes: anticorps CK19, anticorps K19, anticorps K1CS, anticorps AI663979, anticorps EndoC, anticorps Krt-1.19, anticorps Krt1-19, anticorps Ka19, anticorps k19, anticorps ck19, anticorps k1cs, anticorps krt9, anticorps krt15, anticorps MGC76282, anticorps GK-19, anticorps MGC83069, anticorps KRT19, anticorps keratin 19, anticorps keratin 19 L homeolog, anticorps keratin, type I cytoskeletal 19, anticorps KRT19, anticorps Krt19, anticorps krt19, anticorps krt19.L, anticorps LOC100344434, anticorps LOC101117946

Poids moléculaire: 45 kDa

ID gène: 3880

UniProt: P08727