CaMKIIbeta/gamma/delta anticorps (pThr287)

N° du produit ABIN6282451

Détail du produit anti-CaMKIIbeta/gamma/delta anticorps

Antigène: CaMKIIbeta/gamma/delta

Épitope: AA 230-310, pThr287

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CaMKIIbeta/gamma/delta est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: CaMKIIβ/γ/δ is a protein encoded by the CAMK2B gene which is approximately 72,6 kDa. CaMKIIβ/γ/δ is localised to the cytoplasm. It is involved in RET signalling, post NMDA receptor activation events and cardiac conduction. It is a calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation. It plays a role in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. CaMKIIβ/γ/δ is widely expressed in human tissue including the adult and foetal brain. The CAMK2B gene is associated with Phencyclidine abuse. STJ90941 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous CaMKIIβ/γ/δ protein which only binds about T287 when T287 is phosphorylated.

Specificité: Phospho-CaMKIIβ/γ/δ (T287) Polyclonal Antibody detects endogenous levels of CaMKIIβ/γ/δ protein only when phosphorylated at T287.

Attributs du produit: Rabbit polyclonal to Phospho-CaMKIIβ/γ/δ (T287).

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human CaMKIIbeta/gamma/delta around the phosphorylation site of T287.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000

Commentaires:

Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur CaMKIIbeta/gamma/delta

Antigène: CaMKIIbeta/gamma/delta

Abstract: CaMKIIbeta/gamma/delta Produits

Poids moléculaire: 50/65 kDa

ID gène: 816

UniProt: Q13554